N2 CLINIC

Q&A about Stem Cell Therapy

  • What is stem cell therapy?
    Stem cell therapy is a regenerative medicine that uses stem cells for tissue repair. N2Clinic has obtained Codes of the Plans for the Provision of Regenerative Medicine for intravenous administration of adipose tissue-derived stem cells for chronic pain and local administration of adipose tissue-derived stem cells on the face for age-related changes such as wrinkles and sagging.
  • How are the adipocytes collected?
    Normally, about 20-30 ml of subcutaneous fat is collected from the lower abdomen from an inconspicuous area below the navel. An experienced plastic surgeon will collect the adipose tissue using a liposuction technique through a small skin incision of about 2-3 mm.
  • How long does it take from the time of adipose collection to the actual administration of stem cells?
    Because adipose tissue-derived stem cells are isolated from adipose tissue and cultured in a cell processing facility, it takes at least five weeks from the time of adipose tissue collection to the first administration of stem cells. Once isolated, the adipose tissue-derived stem cells are cryopreserved so that subsequent doses of adipose tissue-derived stem cells can be administered within a two-week preparation time.
  • For what diseases are stem cell therapy effective?
    Adipose tissue-derived stem cells have been reported to be effective in treating a large number of diseases. Examples include cerebral infarction, brain contusion, spinal cord injury, multiple sclerosis, hypoxic-ischemic encephalopathy, Parkinson’s disease, Alzheimer-type dementia, ALS (amyotrophic lateral sclerosis), polio (poliomyelitis), peripheral nerve disorder, chronic pain, gonarthrosis, tendon injury, arthritis, intractable bone fractures, palmoplantar pustulosis, atopic dermatitis, acne scars, Vitiligo, AGA (androgenetic alopecia), other alopecia, myocardial infarction, angina pectoris, atherosclerosis, peripheral arterial disease, diabetes mellitus, CKD (chronic kidney disease), liver disease (hepatitis, cirrhosis, liver disorder, etc.), PBC (primary biliary cirrhosis), emphysema, pulmonary fibrosis, chronic obstructive pulmonary disease, autoimmune disease (rheumatoid arthritis, systemic lupus erythematosus, etc.), GVHD (graft-versus-host disease), female menopause, male menopause, prostatic hypertrophy, erectile dysfunction, urinary incontinence, bone defects, osteoporosis, periodontal disease, Post operative-breast cancer (breast reconstruction), breast augmentation, anti-aging therapy (rejuvenation of the skin and blood vessels), COVID-19 infections, sequelae of COVID-19 infections, etc. N2Clinic has obtained Codes of the Plans for the Provision of Regenerative Medicine for intravenous administration of adipose tissue-derived stem cells for chronic pain and local administration of adipose tissue-derived stem cells on the face for age-related changes such as wrinkles and sagging.
  • What is immunotherapy?
    It is a treatment method to improve immunity by multiplying and activating various immune cells in the body through cell culture and then returning them to the body. Because it requires cell processing, it is classified as regenerative medicine. N2Clinic has obtained Codes of the Plans for the Provision of Regenerative Medicine for immunotherapy using various types of immune cells, such as NK cells, dendric cells, alpha-beta T cells, and gamma-delta T cells.
  • How are immune cells collected?
    Targeted immune cells are collected from blood components by apheresis.
  • What kinds of diseases are immunotherapy effective for?
    Because it is a treatment that improves immunity, it has been reported to be effective in cancer treatments, the treatment and prevention of infectious diseases. If you are undergoing other cancer treatments such as surgery, anticancer drug therapy, or radiation therapy, it can also improve the effectiveness of treatments when used in combination.
  • What is culture supernatant?
    Culture supernatant is a cell culture media (supernatant liquid) rich in cytokines and exosomes secreted from the stem cells. Studies on the therapeutic effects of these active ingredients working on cells has been actively conducted, and it is attracting attention as cell free therapy. Since it does not contain stem cells itself, it is not classified as regenerative medicine at this time.
  • What kind of culture supernatants are available?
    The secreted components of mesenchymal stem cells, such as adipose-derived stem cells, bone marrow-derived stem cells, and umbilical cord-derived stem cells, have been reported to be highly effective for treatments. N2Clinic also offers treatments using adipose tissue-derived stem cell culture supernatant and umbilical cord-derived stem cell culture supernatant.
  • Do I need to collect tissue from my own body to have the culture supernatant treatment?
    Culture supernatants do not contain cells, so they are less likely to cause side effects of rejection. There is no need to collect your own tissue, and the procedure can be performed immediately upon request.
  • What kind of diseases is culture supernatant effective for?
    Mesenchymal stem cell culture supernatants have been reported to be effective for a large number of diseases. Examples include cerebral infarction, spinal cord injury, multiple sclerosis, hypoxic-ischemic encephalopathy, Parkinson’s disease, Alzheimer-type dementia, peripheral nerve disorder, chronic pain, gonarthrosis, tendon injury, arthritis, atopic dermatitis, acne scars, vitiligo, AGA (androgenetic alopecia), other alopecia, myocardial infarction, angina pectoris, peripheral artery disease, diabetes mellitus, CKD (chronic kidney disease), liver disease (hepatitis, cirrhosis, liver disorder, etc.), alcoholism, interstitial pneumonia, pulmonary fibrosis, chronic obstructive pulmonary disease, nicotine dependence, pleural effusion, autoimmune disease (rheumatoid arthritis, systemic lupus erythematosus, etc.), allergic disease (allergic conjunctivitis, allergic bronchitis, etc.), Allergic diseases (allergic conjunctivitis, allergic bronchitis, etc.), female menopause, male menopause, prostatic hyperplasia, erectile dysfunction, corneal disorder, visual impairment (presbyopia, etc.), bone defect, periodontal disease, malignant tumor (malignant melanoma, lung cancer, colon cancer, glioma, breast cancer, etc.), anti-aging treatment (rejuvenation of skin, blood vessels, etc.), COVID-19 infection, sequelae of COVID-19 infections, etc.
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  • If I am coming from far away, can you help me with finding accommodation?
    We have a partnership with the Hotel Chinzanso Tokyo, so we can provide you with a hotel plan as well. For further information, please call us.